Efficient synthesis of the C(1)-C(11) fragment of the tedanolides. The nonaldol aldol process in synthesis.
نویسندگان
چکیده
[reaction: see text] The nonaldol aldol process developed in our laboratories has been applied to the synthesis of a C(1)-C(11) fragment 22 of the novel macrocyclic cytotoxic agents tedanolide and 13-deoxytedanolide 1 and 2. The commercially available hydroxy ester 7 was converted in 24 steps into compound 22 using two nonaldol aldol reactions.
منابع مشابه
Synthesis of a fully functionalized protected C1-C11 fragment for the synthesis of the tedanolides.
[figure: see text] The use of several non-aldol aldol processes allows one to prepare a fully functionalized and completely protected C1-C11 fragment that should be useful for the total synthesis of the tedanolides.
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عنوان ژورنال:
- Organic letters
دوره 2 12 شماره
صفحات -
تاریخ انتشار 2000